منابع مشابه
Regulation of neoplastic angiogenesis.
The progressive growth of neoplasms and the production of metastasis depend on the development of adequate vasculature, i.e., angiogenesis. The extent of angiogenesis is determined by the balance between positive- and negative-regulating molecules that are released by tumor and host cells in the microenvironment. The growth of many neoplasms is associated with the absence of the endogenous inhi...
متن کاملAngiogenic heterogeneity: regulation of neoplastic angiogenesis by the organ microenvironment.
Cells cannot survive if they lack adequate oxygen and nutrient supply or cannot dispose of toxic molecules. Oxygen can diffuse from capillaries for only 150–200 m. When distances of cells from a blood supply exceed this, cell death follows (1,2). Thus, the growth and survival of tumor masses beyond 0.5 mm in diameter require neovascularization, i.e., angiogenesis (3). In this issue of the Journ...
متن کاملRegulation of angiogenesis by macrophages.
Abnormal angiogenesis is a cardinal feature in the pathophysiology of several diseases of the retina including retinopathy of prematurity, diabetic retinopathy and choroidal neovascularization associated with age-related macular degeneration. Recent evidence has implicated macrophages as components of the innate immune system that play a key role in regulating angiogenesis in the retina and cho...
متن کاملMechanisms of microRNA-mediated regulation of angiogenesis.
Stroke is the second most common cause of death and consumes about 2-4% of total health-care costs worldwide. Although most studies have focused on neuroprotection during the past decades, current therapeutic options are still very limited. Recently scientists have intensified their work on neurorestorative therapies, including angiogenesis, which allow a far greater time window for improving n...
متن کاملEndocrine and paracrine regulation of endometrial angiogenesis.
The human endometrium is a complex tissue comprised of different cell types, including epithelial, stromal, inflammatory, perivascular, and blood vessel cells. The hormonal receptivity and distribution of these cell populations change during the menstrual cycle. Cyclical endometrial growth is dependent on its ability to regenerate a vascular capillary network, which grows in parallel with the p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JNCI Monographs
سال: 2000
ISSN: 1052-6773,1745-6614
DOI: 10.1093/oxfordjournals.jncimonographs.a024251